The latest shared research on Acta Oncologica
Knockdown of β-Catenin Through shRNA Cause a Reversal of EMT and Metastatic Phenotypes Induced by HIF-1α
Abstract from: Knockdown of β-Catenin Through shRNA Cause a Reversal of EMT and Metastatic Phenotypes Induced by HIF-1α, Jia-Hui Zhao, Yong Luo, Yong-Guang Jiang, Da-Lin He, Chun-Ting Wu, Cancer Investigation Jun 2011, Vol. 29, No. 6, Pages 377-382: 377-382. Objective Wnt/β-catenin signaling pathway regulates pattern formation during embryogenesis as well as tumor progression. Numbers of studies suggest that this signaling pathway may play an important role in Epithelial-Mesenchymal transition (EMT), however, there was no evidence that Wnt/β-catenin signaling pathway directly controlled the EMT occurrence. Our previous research has successfully proved that overexpression of hypoxia inducible factor-1α (HIF-1α) could induce EMT in LNCaP ...
Updated Evidence in Support of Diet and Exercise Interventions in Cancer Survivors
Abstract from: Updated evidence in support of diet and exercise interventions in cancer survivors, Dorothy W. Pekmezi, Wendy Demark-Wahnefried, Acta Oncologica Feb 2011, Vol. 50, No. 2, Pages 167-178: 167-178. Background A growing body of evidence suggests that diet and exercise behaviors and body weight status influence health-related outcomes after a cancer diagnosis. This review synthesizes the recent progress in lifestyle interventions in light of current guidelines put forth by the American Cancer Society (ACS), the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and the American College of Sports Medicine (ACSM). Methods The PubMed database was searched for terms of cancer survivor(s) ...
Late Effects of Breast Cancer Treatment and Potentials for Rehabilitation
Abstract from: Late effects of breast cancer treatment and potentials for rehabilitation, Marianne Ewertz, Anders Bonde Jensen, Acta Oncologica Feb 2011, Vol. 50, No. 2, Pages 187-193: 187-193. Background Breast cancer is the most frequent malignant disease among women world wide. Survival has been improving leading to an increasing number of breast cancer survivors, in the US estimated to about 2.6 million. Material and methods The literature was reviewed with focus on data from the Nordic countries. Results Local therapies such as breast cancer surgery and radiotherapy may cause persistent pain in the breast area, arm, and shoulder reported by 30–50% of patients after three to ...
Latest Roche Research: Clinical Outcome with Bevacizumab in Patients with Recurrent High-Grade Glioma Treated Outside Clinical Trials
Abstract from: Clinical outcome with bevacizumab in patients with recurrent high-grade glioma treated outside clinical trials, Silvia Hofer et al., Acta Oncologica Jun 2011, Vol. 50, No. 5, Pages 630-635: 630-635. Background: Patients with recurrent high-grade glioma (HGG) have a poor prognosis and there is no defined standard of care. High levels of vascular endothelial growth factor (VEGF) expressed in HGG make the anti-VEGF monoclonal antibody bevacizumab (BEV) of particular interest. Patients and methods: In an ongoing registry data were collected from patients who have received BEV for the treatment of recurrent HGG. The primary objective was the identification of any clinical benefit ...
